Hantavirus Replication Cycle—An Updated Structural Virology …
WEBAug 6, 2021 · In this review, we summarize our current understanding of the molecular and structural biology of the hantavirus replication cycle, focusing on recent insights from structural virology studies. We discuss somewhat contradictory hypotheses regarding hantavirus entry, replication, and assembly.
Structural characterization of the oligomerization of full-length ...
WEBMar 13, 2024 · Here we describe the complete cryo-electron microscopy structure of Hantaan virus polymerase in several oligomeric forms. Apo polymerase protomers can adopt two drastically different...
Structures of active Hantaan virus polymerase uncover the …
WEBMay 23, 2023 · Hantaan virus is a lifethreatening Bunyavirus. Here the authors determine the cryoelectron microscopy structure of its polymerase, a central enzyme involved in viral genome replication.
Hantavirus Replication Cycle-An Updated Structural Virology
WEBAug 6, 2021 · In this review, we provide an update on the hantavirus replication cycle with a special focus on structural virology aspects. Keywords: X-ray crystallography; cryo-electron microscopy; cryo-electron tomography; hantaviruses; structural virology; viral fusion glycoproteins; viral genome encapsidation; viral replication; viral transcription ...
Hantavirus entry: Perspectives and recent advances - PMC
WEBAttachment of hantavirus particles to cellular receptors induces their internalization by clathrin-mediated, dynamin-independent, or macropinocytosis-like mechanisms, followed by particle trafficking to an endosomal compartment where the fusion of viral and endosomal membranes can occur.
Hantavirus Gn and Gc Envelope Glycoproteins: Key Structural Units for ...
WEBApr 21, 2014 · Early electron microscopy (EM) studies described hantaviruses as roughly spherical particles of heterogenic size, varying from 70–160 nm [10,11,12,13,14,15]. More recent cryo-electron microscopy (cryo-EM) studies defined their size range between 120–160 nm and also described the presence of elongated particles of …
Viruses | Free Full-Text | Hantavirus Replication Cycle—An …
WEBAug 6, 2021 · A drawing of a hantavirus virion is presented (left) including a top view of the map of the TULV glycoprotein lattice (right), which was obtained by electron cryo-tomography and subvolume averaging (EMD-11236).
Cryofixation of Inactivated Hantavirus-Infected Cells as a Method …
WEBNov 6, 2020 · Abstract. Hantaviruses rewire the host cell and induce extensive membrane rearrangements for their replication and the morphogenesis of the virion. Transmission electron microscopy (TEM) is a powerful technique for imaging these pathological membrane changes especially when combined with large volume electron tomography.
Structural studies of Hantaan virus - PubMed
WEBHantaan virus is the prototypic member of the Hantavirus genus within the family Bunyaviridae and is a causative agent of the potentially fatal hemorrhagic fever with renal syndrome. The Bunyaviridae are a family of negative-sense RNA viruses with three-part segmented genomes.
Diverse Morphology and Structural Features of Old and New …
WEBSep 16, 2019 · Diverse Morphology and Structural Features of Old and New World Hantaviruses. by. Amar Parvate. 1,†, Evan P. Williams. 2, Mariah K. Taylor. 2, Yong-Kyu Chu. 3, Jason Lanman. 1, Erica Ollmann Saphire. 4 and. Colleen B. Jonsson. 2,* 1. Department of Biological Sciences, Purdue University, West Lafayette, IN 47906, USA. 2.