Basic pharmacology of local anaesthetics - PMC - National Center …
WEBDec 4, 2019 · Local anaesthetic drugs are water-soluble salts of lipid-soluble alkaloids. The structure of local anaesthetics consists of three components: a lipophilic aromatic group, an intermediary link and a hydrophilic amine group (Fig. 2).
Topical, Local, and Regional Anesthesia and Anesthetics
WEBAug 28, 2023 · Local anesthetics block voltage-gated sodium channels, which prevents sodium influx into the cell and blocks impulse transmission. Local anesthetics are also class I antiarrhythmic drugs due to the blockade of cardiac sodium channels, with lidocaine being the class IB prototype.
Local anesthetic - Wikipedia
WEBMany local anesthetics fall into two general chemical classes, amino esters (top) and amino amides (bottom).
Local Anesthetics: Review of Pharmacological Considerations
WEBJan 10, 2012 · The intermediate chain or linkage provides a convenient basis for classification of local anesthetics, and also determines their pattern of elimination. Amides are biotransformed in the liver but esters are hydrolyzed in the …
Clinical use of local anesthetics in anesthesia - UpToDate
WEBApr 26, 2024 · Local anesthetics (LAs) are used to block transmission of impulses in nerve fibers, to reduce or eliminate sensation. LAs may be used for neuraxial analgesia and anesthesia, peripheral nerve blocks, subcutaneous …
Classification of local anesthetics - UpToDate
WEBClassification of local anesthetics. Group II. Amides. UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology ...
Local Anesthetics: Introduction and History, Mechanism of Action ...
WEBSep 8, 2023 · Local anesthetics produce anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. This is achieved by anesthetics reversibly binding to and...
Local anesthetics: Video, Anatomy & Definition - Osmosis
WEBLocal anesthetics are medications used to reversibly block pain sensation in a specific part of the body in order to perform small surgical procedures. The common suffix for local anesthetics is -caine, like procaine, tetracaine, lidocaine, Michael Caine - …
Local Anesthetics - ScienceDirect
WEBJan 1, 2022 · Local anesthetics prevent the transmission of nerve impulses from nociceptive afferents, thereby reducing the perception of pain. According to their chemical structure, they are classed as amide or ester local anesthetics. Their use in plastic and reconstructive surgery is widespread.
Local Anesthetics - SpringerLink
WEBMar 14, 2021 · Anesthesia. Anethesiology. Esters. Amides. Local. Spinal. Epidural. 1 Introduction and Historical Overview. Local anesthetics are drugs that possess the potential to produce blunting or loss of sensory perceptions, which is transient and reversible in nature, when administered topically or injected in a confined area.
Skip to content